International CAA Conference

7th International CAA Conference

ONLINE CONFERENCE

30 SEPTEMBER | 1 OCTOBER

Welcome to the 7th International Cerebral Amyloid Angiopathy Conference. We have crafted a program that features cutting-edge research, translational ideas for clinical trials, and new knowledge on prevention and treatment of manifestations of CAA such as hemorrhagic stroke.

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Message from the Chair

Dear participant of the ICAA online Conference,

Please take notice of the following: 

The 7th International CAA Conference has appointed ConventionALL Management Inc. from Calgary, Alberta, Canada as the Virtual Event Organizers. As a registered conference participant you will receive an email in the next week with a username and password, with a link to the Event Day Hub. This Virtual Event Day Hub will have access to all the presentations, research posters and speaker information. If you have any questions regarding access to the 7th International CAA Conference please contact

Kyla Arneson, kyla@conventionall.com.

For any further questions don’t hesitate to contact the Conference desk, office@icaaconference.org

regards,

Eric Smith, MD, MPH

Professor of Neurology, University of Calgary

Chair, 7th International CAA Conference Organizing Committee

This meeting is endorsed by the European Stroke Organization. It is open to all who are interested in cerebrovascular diseases

www.eso-stroke.org

www.eso.kenes.com

Program online conference

WEDNESDAY SEPTEMBER 30
Eastern Daylight Time	Central European Summer Time	Topic	Speaker
9:00-9:10	15:00-15:10	Opening Remarks	Eric Smith, University of Calgary
*Symposium: Cerebral Amyloid Angiopathy as a Transmissable Proteinopathy*
*Chairs: Hamid Sohrabi (Edith Cowan University), David Werring (University College London)*
9:10-9:30	15:10-15:30	Keynote: Prion diseases	John Collinge, University College London
9:30-9:45	15:30-15:45	Iatrogenic CAA: An Emerging Clinical Phenomenon	Gargi Banerjee, University College London
		Oral Abstracts
9:45-9:55	15:45-15:55	MFG-E8 (Lactadherin) accumulates in Aβ-affected cortical vessels in Cerebral Amyloid Angiopathy	Paula Marazuela, Universitat Autònoma de Barcelona
9:55-10:05	15:55-16:05	Early impairments in vasomotion in a mouse model of cerebral amyloid angiopathy	Mariel Kozberg, Massachusetts General Hospital
*Symposium: New Therapeutic Strategies for CAA*
*Chairs: Charlotte Cordonnier (Université de Lille), Dar Dowlatshahi (University of Ottawa)*
10:15-10:30	16:15-16:30	RNA Inhibition Therapies	Roger Lane, Ionis Pharmaceuticals
10:30-10:45	16:30-16:45	Minocycline as a Therapeutic Agent for CAA	Marieke Wermer, Leiden University Medical Center
10:45-11:00	16:45-17:00	Design considerations for CAA trials	Steven Greenberg, Mass General Hospital
		Oral Abstracts
11:00-11:10	17:00-17:10	Patterns of White Matter Hyperintensities define Vascular and Parenchymal Amyloid Burden: a big data imaging approach	Chia-Ling Phuah, Washington University School of Medicine & Barnes-Jewish Hospital
11:10-11:20	17:10-17:20	Cerebral Amyloid Angiopathy is Associated with Affective Dysregulation, Impulse Dyscontrol, and Apathy	Eric Smith, University of Calgary
11:20-11:30	17:20-17:30	Sensitivity of the Edinburgh Criteria for Lobar Intracerebral Hemorrhage in Hereditary Cerebral Amyloid Angiopathy	Ellis van Etten, Leiden University Medical Center
11:30-11:40	17:30-17:40	Idiopathic Primary Intraventricular Hemorrhage and Cerebral Amyloid Angiopathy	Alvin Das, Massachusetts General Hospital
*Panel Discussion*
*Chairs: Eric Smith (University of Calgary), Mark van Buchem (Leiden University Medical Center)*
11:50-12:20	17:50-18:20	Q&A on CAA	Steven Greenberg (Mass General Hospital), Charlotte Cordonnier (University of Lille), David Werring (University College London), Susanne van Velow (Mass General Hospital)
12:20	18:20	Presentation of Poster Prizes

THURSDAY OCTOBER 1
Eastern Daylight Time	Central European Summer Time	Topic	Speaker
9:00-9:05	15:00-15:05	Welcome	Eric Smith, University of Calgary
*Symposium: Biomarkers of CAA*
*Chairs: Sandra Black (University of Toronto), Ashkan Shoamanesh (McMaster University)*
9:05-9:20	15:05-15:20	Biofluid biomarkers of AD and CAA	Ralph Martins, Macquarie University
9:20-9:30	15:20-15:30	PET imaging of CAA	Christopher Rowe, University of Melbourne
9:30-9:40	15:30-15:40	Biomarker Evolution in Presymptomatic HCHWA-D Mutation Carriers	Jeroen van der Grond, Leiden University Medical Center
		Oral Abstracts
9:40-9:50	15:40-15:50	Cerebral amyloid angiopathy is associated with decreased functional brain connectivity	Nadieh Drenth, Leiden University Medical Center
9:50-10:00	15:50-16:00	Composite plasma biomarker score distinguished pre-symptomatic Dutch-type hereditary cerebral amyloid angiopathy mutation carriers from non-carriers	Pratishtha Chatterjee, Macquarie University, School of Medical Health and Sciences, Edith Cowan University

*Symposium: Neurovascular Unit Response to CAA*
*Chairs: Marcel Verbeek (Radboud University), Cheryl Wellington (University of British Columbia)*
10:10-10:25	16:10-16:25	Microvascular architecture in relation to blood flow	Sylvie Lorthois, Institut de Mécanique des Fluides de Toulouse
10:25-10:40	16:25-16:40	Imaging the neurovascular unit response to microbleed	Andrew Shih, University of Washington
10:40-10:55	16:40-16:55	High resolution MRI of microvessel structure/function	Jaco Zwanenburg, University Medical Center Utrecht
		Oral Abstracts
10:55-11:05	16:55-17:05	Spatial Differences in Cerebrovascular Reactivity to Carbon Dioxide Between Patients with Cerebral Amyloid Angiopathy (CAA) and Healthy Controls	Andrew Beaudin, University of Calgary
11:05-11:15	17:05-17:15	Loss of cholinergic innervation differentially affects eNOS-mediated cerebral blood flow, intramural periarterial drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice	Shereen Nizari, University College London

*Symposium: Beta-Amyloid Clearance via Perivascular and Other Drainage Routes*
*Chairs: JoAnne McLaurin (University of Toronto), Julie Schneider (Rush University)*
11:25-11:40	17:25-17:40	Cerebrospinal Fluid and Blood Flow Oscillations in Sleep	Laura Lewis, Boston University
11:40-11:55	17:40-17:55	Perivascular Spaces as a Pathway for Amyloid Clearance	Erik Bakker, VU University Medical Center Amsterdam
11:55-12:10	17:55-18:10	Microvascular dynamics and amyloid clearance	Susanne van Veluw, Mass General Hospital
		Oral Abstracts
12:10-12:20	18:10-18:20	Cerebral amyloid angiopathy aggravates perivascular clearance	Shin Heun Kim, Korea Advanced Institute of Science and Technology
12:20-12:30	18:20-18:30	Cell-type specific transcriptional changes in Dutch-type hereditary cerebral amyloid angiopathy	Tom Metz, Leiden University Medical Center


12:30	18:30	Closing Remarks

Calgary	Boston	CET	Australia (Perth)	Comments
7 am – 11 am	9 am – 1 pm	3 pm – 7 pm	9 pm – 1 am	same day
noon – 4 pm	2 pm – 6 pm	8 pm – 12 am	2 am – 6 am	next day in Australia
4 pm – 8 pm	6 pm – 10 pm	12 am – 4 am	6 am – 10 am	next day in Australia
12 am – 4 am	2 am – 6 am	8 am – 12 pm	2 pm – 6 pm

Reservation Desk

Please register for the 7th International Cerebral Amyloid Angiopathy Conference, to be held online on September 30 and October 1. The theme of the conference is Converting Knowledge to Action: Designing Clinical Trials for CAA.

This conference will be of interest to basic scientists, clinical researchers, and clinicians. The online conference will feature 3 hours of programming each day for two days, additionally with online poster presentations with asynchronous chat with poster presenters. Fourteen lectures will cover topics including new therapeutic approaches to CAA, vascular and perivascular clearance mechanisms for beta-amyloid, pathophysiology of the neurovascular unit in CAA, neuroimaging biomarkers, clinical trial design, and the new diagnostic criteria, the Boston Criteria 2.0.

The reduced registration fees are 50 euros for regular registration, 25 euros for students and trainees. Student registration is open to anyone enrolled in a university graduate or undergraduate program, medical residency, or post-doctoral fellowship program (including MD post-doctoral fellows).

This meeting is endorsed by the European Stroke Organization. It is open to all who are interested in cerebrovascular diseases.

www.eso-stroke.org

www.eso.kenes.com

abstract submission

*****ABSTRACT SUBMISSION DESK CLOSED*****

Dear All,

We are pleased to announce that the virtual online International CAA conference of 30 September | October, 2020, is accepting abstracts for presentation. The deadline for submissions is July 24, 2020

Any basic or clinical science related to CAA is eligible for presentation at the meeting. This includes basic research on causes and mechanisms of CAA, the relationship between CAA and Alzheimer’s Disease, epidemiology, neuropathology, biomarkers, therapeutics, clinical trials, outcomes, and clinical care.

Abstracts will be accepted for oral presentation at the virtual conference, or for presentation at an online e-poster.

We look forward to helping you disseminate your research on CAA.

Sincerely yours,
Eric Smith
Mark van Buchem
Steve Greenberg

Submission Guidelines
– All abstracts must be submitted via office@icaaconference.org ONLY. Abstracts sent by fax will not be accepted.

–        All abstracts should be written in English.
– It is the responsibility of the presenting author and the submitter to review the submission status & information and correct them. Submitters are responsible for any typo error in the abstract.
–        The presenting author’s name should be underlined.
–        The abstract should be limited to;
o   400 words (text only), or
o   300 words and up to 2 images or tables

Important Dates
Call for Abstract                                June 18, 2020
Abstract Submission Due   July 17, 2020

Scientific Program Committee

David Werring FRCP PhD FESO

Professor of Clinical Neurology

UCL Institute of Neurology

Marcel M. Verbeek, PhD MSc

Neurochemist, Associate Professor

Department of Neurology

Radboud university medical center

Hamid R Sohrabi, BSc, MSc, PhD

Research Fellow in Clinical Neurosciences

School of Medical and Health Sciences

Edith Cowan University

Charlotte Cordonnier, MD, PhD,

Professor of Neurology,

Department of neurology & Stroke department

Lille University Hospital Université
Susan van Veluw, PhD

Research Fellow in Neurology

Massachusetts General Hospital

JoAnne McLaurin, PhD

Senior scientist

Sunnybrook Health Sciences Centre

Cheryl Wellington, PhD

Department of Pathology and Laboratory Medicine

Djavad Mowafaghian Centre for Brain Health

University of British Columbia
Sandra Black, OC, O.Ont., MD, FRSC

Senior scientist

Sunnybrook Health Sciences Centre

Ashkan Shoamanesh MD FRCPC

Assistant Professor, Division of Neurology,

Department of Medicine McMaster Univercity

Dar Dowlatshahi, MD PhD FRCP(C)

Senior Scientist, Neuroscience Program

Ottawa Hospital Research Institute

Contact

Organizing Committee 2020