International CAA Conference

7th International CAA Conference

BANFF | CANADA | OCTOBER 1-3 | 2020

Welcome to the 7th International Cerebral Amyloid Angiopathy Conference. We have crafted a program that features cutting-edge research, translational ideas for clinical trials, and new knowledge on prevention and treatment of manifestations of CAA such as hemorrhagic stroke.

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Message from the Chair

Our field of CAA research is being transformed by an expanding array of CAA biomarkers, better radio-pathological correlation, new model systems, and increasing therapeutic options for trials. Attend the Conference to share your own work on CAA, learn about new research and techniques, and gather information on diagnosis and treatment to help your clinical practice. The Conference covers all aspects of CAA research including molecular, tissue- or animal-based, human subject research, and clinical trails. Attendees include basic scientists, clinicians, and clinical researchers.

The 2020 Conference will be held in Banff, a resort town in the specular Canadian Rocky Mountains. Banff is accessed by Calgary International Airport, with direct connections to Frankfurt, Amsterdam, London Heathrow, Paris, Los Angeles, San Francisco, and Tokyo, among others.

We hope to see you in Banff on October 1-3, 2020.

Warmest regards,

Eric Smith, MD, MPH

Professor of Neurology, University of Calgary

Chair, 7th International CAA Conference Organizing Committee

Preliminary Program

****latest news****

Abstract submission will open April 1, 2020. Top ranking abstracts will be presented orally at the Conference.

7^th International CAA Conference – Preliminary Program

Day 1 Thursday October 1

8:30-9:15

Opening Remarks and Keynote Lecture

9:15-10:45	Cerebral Amyloid Angiopathy as a Transmissable Proteinopathy
	Iatrogenic CAA: An Emerging Clinical Phenomenon
	Acquired CAA – Hypotheses for Mechanisms of Seeding
	Experimental Evidence for Amyloid-beta Transmission from Animal Studies
	Oral Abstract Presentations

11:00-12:30	New Therapeutic Strategies for CAA
	RNA Inhibition Therapies
	Beta-amyloid lowering therapies for CAA
	Minocycline as a Therapeutic Agent for CAA
	Oral Abstract Presentations

1:00-3:00

Poster Tours

3:00-4:30	Beta-Amyloid Clearance via Perivascular and Other Drainage Routes
	Vasomotion in Awake Mice and During Sleep
	Perivascular Spaces as a Pathway for Amyloid Clearance
	Imaging CSF and ISF Pulsatility with High-field MRI in Humans
	Oral Abstract Presentations

Day 2 Friday October 2

9:00-10:30	New Biomarkers of CAA
	Biofluid Biomarkers
	Amyloid and Tau PET Imaging
	Version 2.0 of the Boston Criteria
	Oral Abstract Presentations

11:00-12:30	Designing Trials for Hereditary and Non-hereditary CAA
	Biomarker Evolution in Presymptomatic HCHWA-D Mutation Carriers
	Trial Readiness in HCWHA-D Mutation Carriers: Australian and Dutch Experience
	Design Considerations for Trials of CAA
	Panel Discussion

1:00-3:00

Poster Tours

3:00-4:30	Beyond the Boston criteria: is “Pure” CAA a Useful Concept in Non-ICH Cohorts?
	CAA in People With Late-onset Cognitive decline
	CAA in Ischaemic Stroke and TIA Cohorts
	CAA in Convexity Subarachnoid Hemorrhages
	Oral Abstract Presentations

Day 3 Saturday October 3

9:00-10:30	Microvessels, Voxels, and Bleeds
	Microvascular architecture in relation to blood flow
	Imaging the neurovascular unit response to microbleed
	High resolution MRI of microvessel structure/function
	Oral Abstract Presentations

11:00-12:30	Managing Thromboembolic Diseases in CAA
	Managing Atrial Fibrillation When CAA is Present
	Non-Pharmacologic Approaches to Managing Atrial Fibrillation in CAA
	Antiplatelet Therapy After ICH
	Animal and Tissue Models of Vascular Risk Factors and CAA
	Panel Discussion

12:30-12:45

Closing Remarks

Scientific Program Committee

David Werring FRCP PhD FESO

Professor of Clinical Neurology

UCL Institute of Neurology

Marcel M. Verbeek, PhD MSc

Neurochemist, Associate Professor

Department of Neurology

Radboud university medical center

Hamid R Sohrabi, BSc, MSc, PhD

Research Fellow in Clinical Neurosciences

School of Medical and Health Sciences

Edith Cowan University

Charlotte Cordonnier, MD, PhD,

Professor of Neurology,

Department of neurology & Stroke department

Lille University Hospital Université
Susan van Veluw, PhD

Research Fellow in Neurology

Massachusetts General Hospital

JoAnne McLaurin, PhD

Senior scientist

Sunnybrook Health Sciences Centre

Cheryl Wellington, PhD

Department of Pathology and Laboratory Medicine

Djavad Mowafaghian Centre for Brain Health

University of British Columbia
Sandra Black, OC, O.Ont., MD, FRSC

Senior scientist

Sunnybrook Health Sciences Centre

Ashkan Shoamanesh MD FRCPC

Assistant Professor, Division of Neurology,

Department of Medicine McMaster Univercity

Dar Dowlatshahi, MD PhD FRCP(C)

Senior Scientist, Neuroscience Program

Ottawa Hospital Research Institute

Information on Banff and surroundings

Banff is a town within Banff National Park in Alberta, Canada. It is located in Alberta’s Rockies along the Trans-Canada Highway, approximately 126 km (78 mi) west of Calgary and 58 km (36 mi) east of Lake Louise. At 1,400 to 1,630 m (4,590 to 5,350 ft) above sea level,[4] Banff is the community with the second highest elevation in Alberta, after Lake Louise.

There are a number of popular mountains located immediately adjacent to the townsite which include Mount Rundle(2,949 m or 9,675 ft); Cascade Mountain (2,998 m or 9,836 ft); and Mount Norquay (2,134 m or 7,001 ft). Mount Norquay has a ski slope as well as mountain biking trails on the Stoney Squaw portion. A popular tourist attraction, the Banff Gondola, is available to ascend Sulphur Mountain (2,281 m or 7,484 ft) where a boardwalk (Banff Skywalk) beginning from the upper terminal takes visitors to Sanson Peak. Sulphur Mountain is also the location of one of Banff’s most popular attractions, the Banff Upper Hot Springs.

Lake Minnewanka located six minutes north of the townsite is a very popular day use area with a variety of activities. Mountain biking, hiking and fishing are all activities allowed in this part of the park. A very popular Lake Cruise, motor boat rentals and a small food concession are available at the marina.

Tunnel Mountain (formerly known as Sleeping Buffalo Mountain) (1,690 m or 5,545 ft) is situated within the townsite and is very popular for quick hikes; one can reach the summit in less than half an hour. It was named Tunnel Mountain because surveyors initially wanted to make a tunnel for the Canadian Pacific Railway right through the mountain, instead of following the Bow River Valley. Located on the side of Tunnel Mountain is the Banff Centre for Arts and Creativity, which hosts a number of events including outdoor concerts, dance, opera and theatre.

Banff is home to the well-known Banff World Television Festival, Banff Mountain Film Festival, Rocky Mountain Music Festival and Bike Fest. The city is also the starting point of the 4,417 km (2,745 mi) Great Divide Mountain Bike Route, which terminates at Antelope Wells, New Mexico in the United States.

Interesting sites:

www.banfflakelouise.com

www.nomadasaurus.com/things-to-do-in-banff-canada