WEDNESDAY SEPTEMBER 30
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Eastern Daylight Time
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Central European Summer Time
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Topic
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Speaker
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9:00-9:10
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15:00-15:10
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Opening Remarks
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Eric Smith, University of Calgary
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Symposium: Cerebral Amyloid Angiopathy as a Transmissable Proteinopathy
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Chairs: Hamid Sohrabi (Edith Cowan University), David Werring (University College London)
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9:10-9:30
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15:10-15:30
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Keynote: Prion diseases
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John Collinge, University College London
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9:30-9:45
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15:30-15:45
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Iatrogenic CAA: An Emerging Clinical Phenomenon
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Gargi Banerjee, University College London
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Oral Abstracts
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9:45-9:55
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15:45-15:55
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MFG-E8 (Lactadherin) accumulates in Aβ-affected cortical vessels in Cerebral Amyloid Angiopathy
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Paula Marazuela, Universitat Autònoma de Barcelona
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9:55-10:05
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15:55-16:05
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Early impairments in vasomotion in a mouse model of cerebral amyloid angiopathy
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Mariel Kozberg, Massachusetts General Hospital
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Symposium: New Therapeutic Strategies for CAA
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Chairs: Charlotte Cordonnier (Université de Lille), Dar Dowlatshahi (University of Ottawa)
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10:15-10:30
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16:15-16:30
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RNA Inhibition Therapies
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Roger Lane, Ionis Pharmaceuticals
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10:30-10:45
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16:30-16:45
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Minocycline as a Therapeutic Agent for CAA
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Marieke Wermer, Leiden University Medical Center
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10:45-11:00
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16:45-17:00
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Design considerations for CAA trials
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Steven Greenberg, Mass General Hospital
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Oral Abstracts
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11:00-11:10
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17:00-17:10
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Patterns of White Matter Hyperintensities define Vascular and Parenchymal Amyloid Burden: a big data imaging approach
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Chia-Ling Phuah, Washington University School of Medicine & Barnes-Jewish Hospital
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11:10-11:20
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17:10-17:20
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Cerebral Amyloid Angiopathy is Associated with Affective Dysregulation, Impulse Dyscontrol, and Apathy
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Eric Smith, University of Calgary
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11:20-11:30
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17:20-17:30
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Sensitivity of the Edinburgh Criteria for Lobar Intracerebral Hemorrhage in Hereditary Cerebral Amyloid Angiopathy
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Ellis van Etten, Leiden University Medical Center
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11:30-11:40
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17:30-17:40
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Idiopathic Primary Intraventricular Hemorrhage and Cerebral Amyloid Angiopathy
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Alvin Das, Massachusetts General Hospital
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Panel Discussion
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Chairs: Eric Smith (University of Calgary), Mark van Buchem (Leiden University Medical Center)
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11:50-12:20
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17:50-18:20
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Q&A on CAA
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Steven Greenberg (Mass General Hospital), Charlotte Cordonnier (University of Lille), David Werring (University College London), Susanne van Velow (Mass General Hospital)
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12:20
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18:20
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Presentation of Poster Prizes
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THURSDAY OCTOBER 1
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Eastern Daylight Time
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Central European Summer Time
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Topic
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Speaker
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9:00-9:05
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15:00-15:05
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Welcome
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Eric Smith, University of Calgary
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Symposium: Biomarkers of CAA
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Chairs: Sandra Black (University of Toronto), Ashkan Shoamanesh (McMaster University)
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9:05-9:20
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15:05-15:20
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Biofluid biomarkers of AD and CAA
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Ralph Martins, Macquarie University
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9:20-9:30
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15:20-15:30
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PET imaging of CAA
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Christopher Rowe, University of Melbourne
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9:30-9:40
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15:30-15:40
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Biomarker Evolution in Presymptomatic HCHWA-D Mutation Carriers
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Jeroen van der Grond, Leiden University Medical Center
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Oral Abstracts
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9:40-9:50
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15:40-15:50
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Cerebral amyloid angiopathy is associated with decreased functional brain connectivity
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Nadieh Drenth, Leiden University Medical Center
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9:50-10:00
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15:50-16:00
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Composite plasma biomarker score distinguished pre-symptomatic Dutch-type hereditary cerebral amyloid angiopathy mutation carriers from non-carriers
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Pratishtha Chatterjee, Macquarie University,
School of Medical Health and Sciences, Edith Cowan University
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Symposium: Neurovascular Unit Response to CAA
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Chairs: Marcel Verbeek (Radboud University), Cheryl Wellington (University of British Columbia)
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10:10-10:25
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16:10-16:25
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Microvascular architecture in relation to blood flow
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Sylvie Lorthois, Institut de Mécanique des Fluides de Toulouse
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10:25-10:40
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16:25-16:40
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Imaging the neurovascular unit response to microbleed
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Andrew Shih, University of Washington
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10:40-10:55
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16:40-16:55
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High resolution MRI of microvessel structure/function
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Jaco Zwanenburg, University Medical Center Utrecht
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Oral Abstracts
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10:55-11:05
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16:55-17:05
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Spatial Differences in Cerebrovascular Reactivity to Carbon Dioxide Between Patients with Cerebral Amyloid Angiopathy (CAA) and Healthy Controls
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Andrew Beaudin, University of Calgary
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11:05-11:15
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17:05-17:15
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Loss of cholinergic innervation differentially affects eNOS-mediated cerebral blood flow, intramural periarterial drainage of Aβ and cerebral amyloid angiopathy in the cortex and hippocampus of adult mice
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Shereen Nizari, University College London
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Symposium: Beta-Amyloid Clearance via Perivascular and Other Drainage Routes
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Chairs: JoAnne McLaurin (University of Toronto), Julie Schneider (Rush University)
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11:25-11:40
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17:25-17:40
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Cerebrospinal Fluid and Blood Flow Oscillations in Sleep
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Laura Lewis, Boston University
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11:40-11:55
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17:40-17:55
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Perivascular Spaces as a Pathway for Amyloid Clearance
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Erik Bakker, VU University Medical Center Amsterdam
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11:55-12:10
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17:55-18:10
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Microvascular dynamics and amyloid clearance
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Susanne van Veluw, Mass General Hospital
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Oral Abstracts
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12:10-12:20
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18:10-18:20
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Cerebral amyloid angiopathy aggravates perivascular clearance
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Shin Heun Kim, Korea Advanced Institute of Science and Technology
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12:20-12:30
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18:20-18:30
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Cell-type specific transcriptional changes in Dutch-type hereditary cerebral amyloid angiopathy
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Tom Metz, Leiden University Medical Center
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12:30
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18:30
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Closing Remarks
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